DNA methylation controls Foxp3 gene expression
نویسندگان
چکیده
منابع مشابه
DNA methylation versus gene expression.
Vertebrate DNA is methylated at a high proportion of cytosine residues in the sequence CpG, and it has been suggested that the distribution of methylated and non-methylated CpGs in a given cell type influences the pattern of gene expression in those cells. Since a DNA methylation pattern is normally transmitted faithfully to daughter cells via cell division, this idea suggests an origin for sta...
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Regulatory T cells (T reg cells) are a population of CD4+ T cells that limit immune responses. FoxP3 is a master control transcription factor for development and function of these cells, but its regulation is poorly understood. We have identified a T cell receptor-responsive enhancer in the FoxP3 first intron that is dependent on a cyclic-AMP response element binding protein (CREB)/activating t...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2008
ISSN: 0014-2980
DOI: 10.1002/eji.200838105